Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease
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چکیده
منابع مشابه
Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease
IgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly in hemodialyzed patients (prevalence 33%) in whom an elevated incidence of thrombosis and mortality is found. In this paper we have studied the presence of IgA aB2GPI antibodies at pretransplant and their evolution after transplantation with a cross-sectional-based fol...
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Background Graft thrombosis is a devastating complication after renal transplantation. We recently described the association of anti-beta-2-glycoprotein-I (IgA-ab2GP1) antibodies with early graft loss mainly caused by thrombosis in a monocenter study. Methods Multicenter prospective observational cohort study. Setting and participants Seven hundred forty patients from five hospitals of the ...
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BACKGROUND Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported. OBJECTIVE To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians. METHODS Seventy-seven centenarians, 70 ...
متن کاملAnti-interleukin-2 receptor monoclonal antibodies in renal transplantation.
form an IL-2abc complex, which in turn binds IL-2 Although life-long administration of a multi-drug regiwith high affinity ( Kd=10−11 M ). The interaction of men of aspecific small-molecular immunosuppressants IL-2 with this receptor results in a rapid proliferation is most frequently used to prevent rejection of the of the antigen-activated T cells (clonal expansion) leadtransplanted organ, th...
متن کاملHigh avidity anti-beta 2-glycoprotein I antibodies in patients with antiphospholipid syndrome.
OBJECTIVE To evaluate avidity of IgG anti-beta 2-glycoprotein I antibodies (anti-beta2-GPI) in patients with antiphospholipid syndrome (APS) and systemic lupus erythematosus (SLE) in relation to thrombosis, and to demonstrate a possible affinity maturation of IgG anti-beta 2-GPI during the disease course. METHODS 64 sera from 32 patients (18 with primary or secondary APS, 14 with SLE without ...
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ژورنال
عنوان ژورنال: Journal of Immunology Research
سال: 2014
ISSN: 2314-8861,2314-7156
DOI: 10.1155/2014/641962